| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1424976 | Journal of Controlled Release | 2011 | 8 Pages |
Abstract
Pre-conditioning cells within a collagen depot to cell-generated physiological hypoxia up-regulates production of angiogenic factor proteins which are retained by the nano-porous collagen matrix and remain trapped after the seeded cells are killed by snap-freezing. Non-viable angiogenic depots can be (A) embedded into engineered constructs before in vivo implantation or (B) implanted directly into a wound/ischaemic tissue.
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Authors
E. Hadjipanayi, U. Cheema, V. Mudera, D. Deng, W. Liu, R.A. Brown,