| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1425792 | Journal of Controlled Release | 2010 | 8 Pages |
Abstract
Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.
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Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Lior Wolloch, Joseph Kost,