Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1426066 | Journal of Controlled Release | 2009 | 7 Pages |
Amphiphilic copolymers with polylactic acid (PLA) chains grafted onto hyperbranched polyglycerol (HPG) have been synthesized and characterized. The copolymer nanoparticles with corona and core structure were formed by self-assembly in aqueous solution. The loading capacity and association efficiency were up to 23% and 86%, respectively. Protein release profiles with different copolymer compositions and BSA concentrations all showed a burst effect followed by a continuous release phase. The released BSA from the copolymer nanoparticles remained in its original structure over a period of 4 days, as testified by circular dichroism spectroscopy. Furthermore, cell viability research suggested good biocompatibility of the copolymer nanoparticles, which have a promising potential for protein delivery system.
Graphical abstractSupposed mechanisms of BSA encapsulation into the nanoparticles from the HPG-PLA copolymer (nanoprecipitation method).Figure optionsDownload full-size imageDownload as PowerPoint slide