Article ID Journal Published Year Pages File Type
1426107 Journal of Controlled Release 2009 7 Pages PDF
Abstract

Heat treatment is introduced as a simple method for the encapsulation of low molecular weight water-soluble drugs within layer-by-layer assembled microcapsules. A water-soluble drug, procainamide hydrochloride, could thus be encapsulated in large amount and enriched by more than 2 orders of magnitude in the assembled PDADMAC/PSS capsules. The shrunk capsules could control the unloading rate of drugs, and the drugs could be easily unloaded using ultrasonic treatment. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk. We also found that smaller capsules possess higher encapsulation capability.

Graphical abstractA simple method for encapsulating water-soluble small molecular drugs within layer-by-layer assembled PDADMAC/PSS microcapsules is introduced. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Materials Science Biomaterials
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