| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1426452 | Journal of Controlled Release | 2009 | 6 Pages |
Abstract
A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical ingredients (API's). The tablet has a single core formed in a modified oval shape with a semi-permeable coating. The core contains hydroxyethylcellulose, which serves to entrain the API particles as they are extruded out a hole in the coating at one end of the tablet, and a sugar, which provides the osmotic driving force for water imbibing. The dosage form has been successfully shown to control delivery of API over a range of delivery rates even with 50% of the tablet being API (up to about 500 mg).
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Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Kenneth C. Waterman, Bruce C. MacDonald, Michael C. Roy,