Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1427759 | Journal of Controlled Release | 2006 | 18 Pages |
Abstract
The challenge to develop efficient gastroretentive dosage forms began about 20 years ago, following the discovery of Helicobacter pylori by Warren and Marshall. In order to understand the real difficulty of increasing the gastric residence time of a dosage form, we have first summarized the important physiologic parameters, which act upon the gastric residence time. Afterwards, we have reviewed the different drug delivery systems designed until now, i.e. high-density, intragastric floating, expandable, superporous hydrogel, mucoadhesive and magnetic systems. Finally, we have focused on gastroretentive dosage forms especially designed against H. pylori, including specific targeting systems against this bacterium.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
P.L. Bardonnet, V. Faivre, W.J. Pugh, J.C. Piffaretti, F. Falson,