Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1427764 | Journal of Controlled Release | 2006 | 9 Pages |
Abstract
To determine the fate of polymeric micelles after oral administration, we investigated the possible transport of polymeric micelles across Caco-2 monolayers and their biodistribution in rats after per os administration of [14C]-labelled mmePEG750P(CL-co-TMC) micelles containing risperidone (BCS Class II drug). mmePEG750P(CL-co-TMC) was able to cross Caco-2 monolayer via a saturable transport mechanism. The oral bioavailability of the polymer was 40%. Polymeric micelles based on mmePEG750P(CL-co-TMC) showed very low clearance by the reticuloendothelial system (RES) and a renal excretion. A sustained release of risperidone was observed.
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Authors
Frédéric Mathot, L. van Beijsterveldt, V. Préat, M. Brewster, A. Ariën,