| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428106 | Materials Science and Engineering: C | 2015 | 12 Pages |
•Biosynthesis of gold and silver nanoparticles using plant leaf extract•The approach is clean, efficient, eco-friendly & economically safe.•Biosynthesized nanoparticles are biocompatible towards normal and cancer cells.•Design and development of biosynthesized nanoparticle based drug delivery systems•Biosynthesized nanoparticles could be useful for cancer and other diseases.
In the present article, we demonstrate the delivery of anti-cancer drug to the cancer cells using biosynthesized gold and silver nanoparticles (b-AuNP & b-AgNP). The nanoparticles synthesized by using Butea monosperma (BM) leaf extract are thoroughly characterized by various analytical techniques. Both b-AuNP and b-AgNP are stable in biological buffers and biocompatible towards normal endothelial cells (HUVEC, ECV-304) as well as cancer cell lines (B16F10, MCF-7, HNGC2 & A549). Administration of nanoparticle based drug delivery systems (DDSs) using doxorubicin (DOX) [b-Au-500-DOX and b-Ag-750-DOX] shows significant inhibition of cancer cell proliferation (B16F10, MCF-7) compared to pristine drug. Therefore, we strongly believe that biosynthesized nanoparticles will be useful for the development of cancer therapy using nanomedicine approach in near future.
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