| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428239 | Materials Science and Engineering: C | 2015 | 8 Pages |
•Preparation of novel micro-porous matrix with different physiochemical proprieties•S. coelicolor A3(2) was cultured in those micro-porous and antibiotics was enhanced.•Matrix pore sizes and surface chemistry influenced bacterial signalling.•Bacterial signalling has a profound effect in the overproduction of Prodigiosin and actinorhodin.•Prodigiosin and actinorhodin production within micro-porous was 5–17 times higher compared with liquid growth.
A novel functionalized micro-porous matrix was developed with well-controlled physicochemical proprieties such as pore size and surface chemistry. The matrix was used as a solid support in the growth of “Streptomyces coelicolor” A3(2) to enhance the production of antibiotics. The results shown support a higher production of prodigiosin and actinorhodin with overall production increase of 2–5 and 6–17, respectively, compared to conventional submerged liquid culture, offering a potential improvement in volumetric productivity.Scanning Electron Microscopy was used to evaluate pore size as well as bacterial adhesion, penetration, proliferation and migration within the micro-porous matrix.
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