| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428372 | Materials Science and Engineering: C | 2015 | 9 Pages |
•Delivery of anti-leukemic drugs is improved by application of nanotechnology.•Intracellular delivery of nanoparticles in leukemia cells is addressed.•Nanoparticles exhibit immense potential in detection and diagnosis of leukemia.•The review highlights the use of nanoparticles in reversal of MDR in leukemia.
The conventional chemotherapy for leukemia involves frequent dosing, severe side effects and lack of specificity of such anticancer drugs. The treatment with most of the anti-leukemic drugs would be improved if they were delivered to their biological targets through appropriate application of nanotechnology by manipulating at the molecular level. Nanoparticles in the recent years have shown tremendous application with respect to diagnosis and treatment of leukemia. The review specifically focuses on the use of nanoparticles for sustaining the release of anti-leukemic drugs and intracellular delivery of such nanoparticles. The review also highlights the application of nanoparticles in reversal of multidrug resistance.
Graphical abstractA. Development of blood cells from bone marrow, B. normal blood, C. blood during leukemia.Figure optionsDownload full-size imageDownload as PowerPoint slide
