| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428503 | Materials Science and Engineering: C | 2015 | 7 Pages |
•The formation mechanism of PPy nanoarchitectures was proposed.•CS acted as biofunctional dopant and morphology-directing agent in PPy forming.•PPy-CS nanoarchitectures were dependent on the Py/CS ratio.
Nanospheres, nanocones, and nanowires are three typical polypyrrole (PPy) nanoarchitectures and electrochemically polymerized with the dope of chondroitin sulphate (CS) in this study. CS, a functional biomacromolecule, guides the formation of PPy nanoarchitectures as the dopant and morphology-directing agent. Combined with our previous reported other PPy nanoarchitectures (such as nanotube arrays and nanowires), this work further proposed the novel mechanism of the construction of PPy/CS nanoarchitectures with the synergistic effect of CS molecular chains structure and the steric hindrance. Compared to the undoped PPy, MC3T3-E1 cells with PPy/CS nanoarchitectures possessed stronger proliferation and osteogenic differentiation capability. This suggests that PPy/CS nanoarchitectures have appropriate biocompatibility. Altogether, the nanoarchitectured PPy/CS may find application in the regeneration of bone defect.
