| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428617 | Materials Science and Engineering: C | 2014 | 5 Pages |
•Methylprednisolone loaded nanoparticles was prepared for drug delivery.•In vitro cytotoxicity tests revealed the nanoparticles have good biocompatibility.•Nanoparticles would have great potential in synergetic effect treatment for spinal cord injury.
Ibuprofen modified inulin was synthesized through a direct esterification linkage in which the in situ activation of the carboxylic acid with N,N′-carbonyldiimidazole was carried out. The critical aggregation concentration of the ibuprofen modified inulin was determined by using pyrene as the fluorescence probe. Methylprednisolone loaded nanoparticles were prepared by the self-assembly of the ibuprofen modified inulin copolymer and methylprednisolone. In vitro release of the methylprednisolone and the cytotoxicity of the methylprednisolone loaded nanoparticles against RSC-96 cells were evaluated. Since the ibuprofen and methylprednisolone could stimulate a significant neurite growth and diminish the human neurological deficits after the spinal cord injury, the methylprednisolone loaded nanoparticles based on the ibuprofen modified inulin copolymer may have a great potential in the synergetic effect treatment for spinal cord injury.
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