| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428757 | Materials Science and Engineering: C | 2014 | 8 Pages |
•A magnetic dual-drug delivery system has been synthesized successfully.•Metformin HCl and ibuprofen were used as model drugs, and the system shows the different drug release kinetics for them.•The material has good attachment with Hela cells.
The hierarchical porous bioglass combined with magnetic SBA-15 was synthesized. The bioactive glass materials possess a hierarchical porous structure with the macroporous (50 μm) and the mesoporous (3.86 nm) structures derived from the plant template (cattail stem) and triblock polyethylene oxide-propylene oxide block copolymer (P123), respectively. Magnetic SBA-15 was synthesized by adopting the post assembly method using Fe(NO3)3 as iron source and ethylene glycol as reduction. After coating PLGA, PLGA-IBU-magnetic SBA-15 also possessed super-paramagnetism and the corresponding saturation magnetizations (Ms) could reach 2.6 emu g− 1. Metformin HCl (MH) and ibuprofen (IBU) were used as model drugs, and the drug release kinetics was studied. MH and IBU could release 60% and 85% from the sample respectively. The system shows excellent dual-drug controlled delivery performance and good bioactivity in vitro that leads to good potential application on bone regeneration.
