| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1428771 | Materials Science and Engineering: C | 2014 | 7 Pages |
•The porous PLGA microparticles were successfully prepared by the electrospray deposition method at one step.•The porous microparticles had high loading capacity and low density.•The microparticle showed a sustained release in the simulated gastric liquid.•The microparticles showed a slight cytotoxicity in vitro.
In the present study, the electrospray deposition was successfully applied to prepare the porous poly(lactic-co-glycolic acid) (PLGA) microparticles by one-step processing. Metronidazole was selected as the model drug. The porous PLGA microparticles had high drug loading and low density, and the porous structure can be observed by scanning electron microscope (SEM) and transmission electron microscopy (TEM). The production time has been shortened considerably compared with that of the traditional multi-emulsion method. In addition, no chemical reaction occurred between the drug and polymer in the preparation of porous microparticles, and the crystal structure of drug did not change after entrapment into the porous microparticles. The porous microparticles showed a sustained release in the simulated gastric fluid, and the release followed non-Fickian or case II transport. Furthermore, porous microparticles showed a slight cytotoxicity in vitro. The results indicated that electrospray deposition is a good technique for preparation of porous microparticles, and the low-density porous PLGA microparticles has a potential for the development of gastroretentive systems or for pulmonary drug delivery.
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