| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1429450 | Materials Science and Engineering: C | 2013 | 6 Pages |
The characterization, inclusion complexation behavior and binding ability of the inclusion complexes of mangiferin (MGF) with β-cyclodextrin and its derivatives (hydroxypropyl-β-cyclodextrin (HPβCD), sulfobutyl ether β-cyclodextrin (SBEβCD) and mono (6-ethylene-diamino-6-deoxy)-β-cyclodextrin (ENβCD)) were investigated in both solution and solid state by means of PL spectroscopy, 1H and 2D NMR, XRD, TG and DSC. The results showed that the water solubility and thermal stability of MGF were significantly increased in the inclusion complex with cyclodextrins. The MGF/CDs complexes will be potentially useful for the design of a novel formulation of mangiferin for herbal medicine.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Four mangiferin/cyclodextrin inclusion complexes were prepared and confirmed. ► The inclusion complexation behaviors were investigated. ► The possible inclusion modes of mangiferin with cyclodextrins were obtained. ► The aqueous solubility of the complexes was much higher than that of mangiferin. ► The thermal stability of the complexes was enhanced significantly.
