Synthesis and characterization of a potential material as internal fixation of bone fracture

A new unsaturated poly (ester-amide) viz phthalic anhydride-maleic anhydride-hexane diamine-ethylene glycol-neopentylene glycol copolymer was prepared by melt polycondensation and characterized after sealed end with benzyl alcohol. Mechanical properties and degradation behavior of the cross-linked unsaturated poly (ester-amide) were measured. Moreover, the hydrolysis behavior of cross-linked unsaturated poly (ester-amide) in 1.0 mol/L NaOH standard solution at room temperature was also studied. At the same time, preliminary biocompatibility under mice skin was evaluated. All the preliminary results suggested that the copolymer might be a potential bone internal fixation material.