| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1430335 | Materials Science and Engineering: C | 2009 | 6 Pages |
Abstract
The aim of this study was to obtain microparticles containing acyclovir (ACV) and chitosan cross-linked with tripolyphosphate using the spray-drying technique. The resultant system was evaluated through loading efficiency, differential scanning calorimetry (DSC), thermogravimetric analysis (TG), X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), in vitro release and stability studies. The results obtained indicated that the polymer/ACV ratio influenced the final properties of the microparticles, with higher ratios giving the best encapsulation efficiency, dissolution profiles and stability. The DSC and XRPD analyses indicated that the ACV was transformed into amorphous form during the spray-drying process.
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Authors
Hellen Karine Stulzer, Monika Piazzon Tagliari, Alexandre Luis Parize, Marcos Antonio Segatto Silva, Mauro Cesar Marghetti Laranjeira,