Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1430452 | Materials Science and Engineering: C | 2009 | 4 Pages |
Abstract
Chitosan–sodium alginate microcapsules were prepared in the presence of ZnS nanoparticles via the W/O/W emulsification solvent-evaporation method. Microscopy showed that the microsphere was about 150 nm and by the absorption spectra, ZnS nanoparticles incorporated was 4 nm. Aspirin was chosen to investigate the effect of microcapsules on the drug release. It reveals that comparing with the microsphere without nanoparticles, the release speed of microsphere containing ZnS nanoparticles is significantly decreased from complete release at 10 h to 50% release by 50 h. The data of release kinetics for the microcapsules can be well fitted by the classic Higuchi model.
Keywords
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Zhulai Li, Peng Chen, Xiuzhi Xu, Xiao Ye, Jin Wang,