| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 144480 | Advanced Powder Technology | 2015 | 7 Pages |
•The impact of impurity on the growth behaviour of a crystal population is modelled.•The study is enabled by a morphological population balance model.•The study is for β L-glutamic acid crystals and the additive is L-phenylalanine.•Simulation results were verified in experiments.
This short communication investigates the impact of impurity on crystal growth behaviour in terms of crystal shape distribution. A two dimensional population balance model is applied to study the crystal shape changing behaviour in cooling crystallisation producing β-form L-glutamic acid crystals, in the presence and without the presence of an additive, L-phenylalanine. The simulation results were verified in experiments using a 1-litre crystalliser for crystallisation of L-glutamic acid.
Graphical abstractThe evolution of shape distribution for the seeded crystallisation of L-glutamic acid in the presence of an impurity, L-phenylalanine. It was found that the impurity did not have much influence on the width direction, but has inhibited the growth in the length direction.Figure optionsDownload full-size imageDownload as PowerPoint slide
