Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1462466 | Ceramics International | 2012 | 8 Pages |
Bioactive magnetite nanoparticles were prepared successfully by coating magnetite nanoparticles with CaSiO3 followed by their immersion in simulated body fluid. The Fe3O4 nanoparticles (5–10 nm) were synthesized by a co-precipitation technique. In order to prepare core–shell nanocomposites, the nanoparticles were soaked for 1 h in a calcium silicate solution that had been aged for 24 h before using it. The samples were dried in air and then immersed in SBF at 37 °C for 1, 3 and 7 days. The analyses of the samples after the biomimetic process revealed the formation of a bonelike apatite layer on all the samples tested and not a significant change was observed on their original magnetic behavior. Hemolysis test, evaluated as release of hemoglobin, revealed that all the samples showed no hemolytic effects up to 3 mg/ml, indicating no damage of the red blood cell membranes. These bioactive, hemocompatible and superparamagnetic particles may be potential materials for bone cancer treatment by hyperthermia.