| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1473357 | Journal of Asian Ceramic Societies | 2014 | 6 Pages |
Abstract
Silica nanoparticles containing covalently linked iodine and a near-infrared (NIR) fluorescence dye, namely porphyrin, have been synthesized through a one-pot sol–gel reaction. These particles are called iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs). The ISP HNPs have both high X-ray absorption coefficient and NIR fluorescence. The ISP HNPs modified with folic acid (FA) and polyethylene glycol (PEG), denoted as FA-PEG-ISP HNPs, enabled the successful visualization of tumors in mice by both X-ray computed tomography (CT) and fluorescence imaging (FI). Thus, the FA-PEG-ISP HNPs are useful as contrast agents or probes for CT/FI dual-modal imaging.
Related Topics
Physical Sciences and Engineering
Materials Science
Ceramics and Composites
Authors
Koichiro Hayashi, Sakamoto Wataru, Toshinobu Yogo,