| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1488709 | Materials Research Bulletin | 2013 | 4 Pages |
Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N2 adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between NH3+ on the matrix and COO−belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ► The materials have high surface area and amino group. ► The materials show higher drug loading and slower release rate than pure HAP.
