Article ID Journal Published Year Pages File Type
1488784 Materials Research Bulletin 2013 4 Pages PDF
Abstract

•Adsorption of methylene blue (MB) on graphene oxide (GO).•Characterization of graphene oxide–methylene blue nanocomposite (MB–GO).•Examination of MB–GO efficiency in singlet oxygen generation (SOG).•MB–GO performs higher SOG efficiency than pristine MB.

Due to unique electronic, mechanical, optical and structural properties, graphene has shown promising applications in many fields, including biomedicine. One of them is noninvasive anticancer therapy – photodynamic therapy (PDT), where singlet oxygen (SO), generated under the irradiation of light with appropriate wavelengths, kills cancer cells. In this study, authors report graphene oxide (GO) noncovalent functionalization with methylene blue (MB). MB molecules underwent adsorption on the surface of GO. Detailed characterization of the obtained material was carried out with UV–vis spectroscopy, Raman spectroscopy, FT-IR spectroscopy, and confocal laser scanning microscopy. Furthermore, its performance in singlet oxygen generation (SOG) under irradiation of laser with excitation wavelengths of 785 nm was investigated. Interestingly, GO functionalized with MB (MB–GO) showed enhanced efficiency in singlet oxygen generation compared to pristine MB. The efficiency in SOG was detected by photobleaching of 9,10-anthracenediyl-bis(methylene)dimalonic acid (ABMDMA). These results indicate the material is promising in PDT anticancer therapy and further in vitro and in vivo studies are required.

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Related Topics
Physical Sciences and Engineering Materials Science Ceramics and Composites
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