Facile fabrication of ibuprofen–LDH nanohybrids via a delamination/reassembling process

In this paper, a delamination/reassembling method for the facile fabrication of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, intercalated layered double hydroxide (LDH) nanohybrid was presented. In this method, LDH particles were first delaminated to well dispersed 2D nanosheets in formamide, and then the LDH nanosheets and IBU molecules coassembled into the IBU–LDH nanohybrid. The characteristics of the so-synthesized nanohybrid were the same as that of the IBU–LDH nanohybrids synthesized by the conventional methods including ion exchange, co-precipitation, reconstruction and hydrothermal methods. However, the delamination/reassembling method displayed various remarkable advantages, such as simple procedure, short reaction time, mild condition and high drug loading, compared with the conventional methods.

Graphical abstractIbuprofen intercalated layered double hydroxide (LDH) nanohybrid was successfully synthesized via a delamination/reassembling process. This method shows various remarkable advantages, such as simple procedure, short reaction time, mild condition, and high drug loading.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► IBU–LDH nanohybrid was synthesized via a delamination/reassembling process. ► This method shows various advantages compared with conventional methods. ► The loading amount of IBU can exceed that determined by the charge-balancing law.