Nanoporous gold for enzyme-free electrochemical glucose sensors

We report the detection of non-enzyme electrochemical glucose using nanoporous gold (NPG) as electrodes. The free-standing NPG films showed a robust and sensitive current response to glucose. The effects of pore sizes, detecting potentials and chloride ions on glucose oxidation were systematically investigated. NPG with a smaller pore size possesses higher sensitivity. In addition, the NPG electrodes can effectively avoid interference from the oxidation of common organic interferents in body liquids. The high sensitivity and selectivity make NPG promising electrodes for applications in electrochemical biosensors.