Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1520812 | Materials Chemistry and Physics | 2016 | 7 Pages |
Abstract
Study and development of drug delivery nanosystem for cancer treatment are attracting great attention in recent years. In this work, we studied the role of folic acid as a targeting factor on magnetic nanoparticle Fe3O4 based curcumin loading nanosystem. Characteristics of the nanosystems were investigated by Fourier transform infrared spectroscopy (FTIR) and field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA) and vibrating sample magnetometer (VSM), while targeting role of folic was accessed in vivo on tumor bearing mice. The results showed that folate attached Fe3O4 based curcumin loading nanosystem has very small size and exhibits better targeting effect compared to the counterpart without folate. In addition, magnetic induction heating of this nanosystem evidenced its potential for cancer hyperthermia.
Keywords
Related Topics
Physical Sciences and Engineering
Materials Science
Electronic, Optical and Magnetic Materials
Authors
Le Thi Thu Huong, Nguyen Hoai Nam, Do Hai Doan, Hoang Thi My Nhung, Bui Thuc Quang, Pham Hong Nam, Phan Quoc Thong, Nguyen Xuan Phuc, Ha Phuong Thu,