| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1526035 | Materials Chemistry and Physics | 2009 | 5 Pages |
Abstract
A water-soluble macromonomer (PEG-β-CD) was synthesised by reaction of β-cyclodextrin with poly(ethylene glycol) diglycidyl ether. Then, a novel hydrogel with pH-sensitivity was prepared by irradiating the mixture of acrylic acid and PEG-β-CD with electron beam. Compared with the normal PAAc hydrogel, this novel hydrogel had a higher swelling ratio at pH 3–8. 5-Fluorouracil (5-FU) was chosen as a model drug, and the kinetics of 5-FU releasing behavior was studied. Compared with the PAAc hydrogel, the results showed the release time of 5-FU from the cyclodextrin containing hydrogel was prolonged. It may be ascribed to the formation of inclusion complexes between the drug molecules and cyclodextrin groups.
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Authors
Jie Chen, Liang Rong, Han Lin, Ruijia Xiao, Huifeng Wu,