Contrast enhancement using Mie spectra representation for spectroscopic optical coherence tomography

The paper presents a spectroscopic optical coherence tomography (SOCT) method that offers a tomography imaging contrast in scatterer size. In the method, the depth resolved spectroscopy is modelled as a linear combination of basis spectra from scatterers in a prescribed dictionary. The depth resolved spectroscopy is first reconstructed by searching the optimal expansion of the SOCT spectral measurement over the basis spectra. Then the scatterer sizes corresponding to the spectra in the optimal expansion are used to display the SOCT image. Simulation and experimental studies demonstrated that the proposed contrast can differentiate the scatterer clusters in samples.