Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1534663 | Optics Communications | 2014 | 4 Pages |
We investigated the evolution dynamics of sensor signal for the binding of the bovine serum albumin (BSA) molecules to the metallic photonic crystals (MPCs). Measurements on the BSA/phosphate solution indicate a sensitivity as high as 1 ng/ml of the MPC sensor device. The experimental results show a highly nonlinear relationship between the amplitude of the sensor signal and the BSA concentration, where the binding rate increases with the increase in the concentration of the BSA/phosphate solution. Furthermore, there exists an upper limit of the concentration of the BSA/phosphate solution as low as 1 mg/ml for sensor applications, which is determined such that no refractive index change is introduced due to the increase in the solution concentration.