Modeling continuous high-shear wet granulation with DEM-PB

•Coupling DEM and PB modeling methods in high-shear continuous granulation.•DEM model validation with step responses.•PB model construction based on the DEM simulations.•Validating the developed DEM-PB model with experimental PSD.•Shaft speed dependence effect on the granulator dynamics.

A multiscale modeling procedure is introduced in this paper for modeling continuous high-shear wet granulation. Flow inside the granulator is accounted using the discrete element method (DEM) and particle-level interactions with population balance (PB). The developed DEM-PB model is validated against experiments, particle size distribution (PSD), and residence time distribution (RTD). It was observed that the model gave good correspondence to the experimental values. The developed methodology can be used when designing continuous granulation processes.

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