| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1548230 | Progress in Natural Science: Materials International | 2014 | 4 Pages |
Abstract
Application of viral vector in gene therapy and vaccination is still limited by their structural stability, which significantly increased avoidable cost in storage and transportation. Herein a non-covalent conjugated low-pH degradable nanocapsule has been adopted to stabilize viral vectors. By utilizing a luciferase expressing adenovirus, AdCMVLuc, we succeeded in a raise of over 11 folds in AdCMVLuc׳s structural stability after 12 days storage at 4 °C.
Keywords
Related Topics
Physical Sciences and Engineering
Materials Science
Electronic, Optical and Magnetic Materials
Authors
Ding Weng, Ziyue Karen Jiang, Jing Jin, Lily Wu, Yunfeng Lu,