Article ID Journal Published Year Pages File Type
1548672 Progress in Natural Science: Materials International 2008 6 Pages PDF
Abstract

Protective effect of inosine against cell death after photochemically induced focal cerebral ischemia was investigated in adult rats. Intraperitoneal injection of inosine was started 24 h before operation and continued till the animals were sacrificed. The TUNEL method and Nissl staining were used to identify apoptosis and necrosis, respectively. TUNEL-positive cells were located in the transitional zone between the necrotic core and normal cortex. The mean maximum area of the necrotic cores and mean number of TUNEL-positive cells 24 h after operation were reduced significantly in the inosine-treated rats when compared with those in the saline-treated control animals. We suggest that inosine can significantly reduce both necrosis and apoptosis following cerebral ischemia induced by photothrombosis in adult rats.

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Physical Sciences and Engineering Materials Science Electronic, Optical and Magnetic Materials
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