Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1549093 | Progress in Natural Science: Materials International | 2008 | 4 Pages |
Abstract
By ESR spin elimination and photocleavage assay, the mechanisms of one-electron oxidation damage of oligonucleotides by excited triplet state of riboflavin (Rb) have been elucidated. The results demonstrate that Rb, an endogenous photosensitizer, is capable of cleaving single-stranded telomeric overhang and the template region of telomerase RNA under UVA irradiation, resulting in blocking of reverse transcription of telomeric DNA which leads to the apoptosis of cancer cells ultimately.
Related Topics
Physical Sciences and Engineering
Materials Science
Electronic, Optical and Magnetic Materials
Authors
Yuxia Liu, Fuqiang Du, Weizhen Lin, Tiecheng Tu, Wenxin Li, Nianyun Lin,