Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
156541 | Chemical Engineering Science | 2011 | 7 Pages |
Abstract
Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Yoshitoshi Saito, Xianfeng Fan, Andy Ingram, Jonathan Peter Kyle Seville,