Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1589051 | Micron | 2014 | 7 Pages |
Abstract
Nanoportals at the cell plasma membrane called porosomes, mediate secretion from cells. In neurons porosomes are 15Â nm cup-shaped lipoprotein structure composed of nearly 40 proteins. The size and complexity of the porosome has precluded determination of its atomic structure. Here we report at nanometer resolution the native 3D structure of the neuronal porosome-synaptic vesicle complex within isolated nerve terminals using small-angle X-ray solution scattering. In addition to furthering our understanding of the porosome structure, results from the study suggests the molecular mechanism involved in neurotransmitter release at the nerve terminal.
Related Topics
Physical Sciences and Engineering
Materials Science
Materials Science (General)
Authors
Ladislau C. Kovari, Joseph S. Brunzelle, Kenneth T. Lewis, Won Jin Cho, Jin-Sook Lee, Douglas J. Taatjes, Bhanu P. Jena,