Article ID Journal Published Year Pages File Type
159944 Chemical Engineering Science 2006 10 Pages PDF
Abstract

Escherichia coli has been the most widely used host for the production of recombinant proteins because it is the best characterized system in every aspect. Furthermore, the high cell density culture of recombinant E. coli has allowed production of various proteins with high yield and high productivities. Various cultivation strategies employing different host strains and expression systems have been successfully employed for the production of recombinant proteins. New strategies for strain improvement towards the goal of enhanced protein production are actively being developed based on high-throughput omics approaches such as transcriptomics and proteomics. This paper reviews recent advances in the production of recombinant proteins by high cell density culture of E. coli.

Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
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