Article ID Journal Published Year Pages File Type
1642173 Materials Letters 2016 4 Pages PDF
Abstract
Biodegradable shape-memory poly(ε-caprolactone) (PCL)/trisilanolphenyl polyhedral oligomeric silsequioxane (TspPOSS) nanocomposite films loaded with drug (theophylline) were prepared by a solution blending followed by solvent casting method. PCL/TspPOSS nanocomposite (90 wt/10 wt) loaded with 10 wt% drug exhibited fairly good thermally-triggered shape memory behavior with a shape fixity ratio of 81% and shape recovery ratio of 85%. In vitro drug release studies in the phosphate buffer solution (PBS; pH=7.4) revealed that the TspPOSS nanocrystals caused sustained release of the drug for the nanocomposites. It was also shown that TspPOSS enhanced the hydrolytic degradation rate of the PCL matrix.
Related Topics
Physical Sciences and Engineering Materials Science Nanotechnology
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