| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1642790 | Materials Letters | 2015 | 4 Pages |
•We synthesize HGNs with an NIR absorption peak of specific wavelength.•Pegylation is used to combine HGNs with the monoclonal antibody of cMet.•We prove cMet overexpresses on the membrane of HeLa and CaSki by IF.•NIR with presence of anti-cMet conjugated HGNs induces a growth in apoptosis rate.•Laser irradiation leads cancer cells apoptosis by disrupting Bcl-2/Bax balance.
The aim of our study was to investigate whether anti-cMet antibody conjugated hollow gold nanospheres (anti-cMet/HGNs) could enhance the sensitivity of photothermal ablation therapy on cervical cancer. Photothermal therapy in vitro was conducted on HeLa and CaSki using near-infrared ray (1.7 J/cm2) in four groups: control, laser only, hollow gold nanospheres (HGNs) with laser and anti-cMet/HGNs with laser. Compared with other groups, group of anti-cMet/HGNs with laser possessed a higher early apoptotic rate by 5.83% in HeLa and 20.0% in CaSki. Meanwhile, this group indicated an overexpression of Caspase-3, Bax and Cyclin E2. Anti-cMet/HGNs had potentials to enhancing the effect of photothermal therapy on cervical cancer by disrupting the balance between Bcl-2 and Bax.
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