Preparation and characterization of novel CdSe quantum dots modified with poly (d, l-lactide) nanoparticles

In this paper, novel CdSe quantum dots (QDs) modified with poly (d, l-lactide) (PLA) nanoparticles by nanoprecipitation method was reported. CdSe QDs modified with PLA nanoparticles were characterized by Photon correlation spectroscope (PCS), transmission electron microscope (TEM), flluorescence spectrophotometer and fluorescence microscope. The modified CdSe QDs were spherical and relatively uniform. The modified CdSe QDs were water soluble and their strong yellow fluorescence emission was observed both in vitro and in vivo. The fluorescence of the modified CdSe QDs was stable in aqueous solution for more than 30 d. These modified CdSe QDs are expected to have much potential for biological labeling and diagnostics based on above properties.