Biocompatibility control of recombinant collagen by ion beam modification

► Recombinant collagen was modified by 150 keV He+ ion beam to control the biological responses. ► Platelet response was significantly inhibited at a fluence of 1 × 1014 ions/cm2. ► The cell-adhesive property still remained at the fluences of 1 × 1014 ions/cm2 or less. ► The surface modified with a fluence of 1 × 1014 ions/cm2 not only retains cell-adhesive property but also possesses anti-thrombogenicity.