| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1671481 | Thin Solid Films | 2009 | 5 Pages |
Abstract
A nanoporous polymer thin film has been developed as a potential platform for drug delivery. The film was fabricated by a light-induced polymerization process in which non-reactive solvent was first separated from photopolymer (dipentaerythritol penta-/hexa-acrylate as the monomer) and then removed from polymer via evaporation, yielding pores with diameters between 20 and 40Â nm. Loading and release of Rhodamine B (drug model molecules) on both porous and non-porous thin films proved that nanopores enhanced the film's effectiveness in encapsulating and releasing the drug model molecules, which was attributed to the high surface-to-volume ratio of nanoporous film. Ultrasound-enhanced cumulative and pulsatile release revealed the advantages of ultrasound in controlled drug delivery.
Related Topics
Physical Sciences and Engineering
Materials Science
Nanotechnology
Authors
Wei Yan, Vincent K.S. Hsiao, Yue Bing Zheng, Yasir M. Shariff, Tieyu Gao, Tony Jun Huang,