Article ID Journal Published Year Pages File Type
1681726 Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2014 5 Pages PDF
Abstract

In this study, two types of microcapsules were designed: (1) computed tomography (CT)-detectable anti-αvβ3 (E[c(RGDfK)]2) microcapsules, containing P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1), for the observation of metastases through αvβ3-antigen–antibody accumulation; and (2) metastasis-targeting microcapsules that upon irradiation release anticancer drugs with high affinity for P-selectin. These microcapsules were tested on C3He/N mice with MM48 tumors undergoing two radiotherapy sessions.The injected anti-αvβ3 microcapsules accumulated in the vascular endothelium of metastatic tissues and could be detected by CT. These microcapsules released P-selectin in response to the first irradiation, which was also induced in the endothelium of vessels in the case of metastasis. The microcapsules used for radiosensitizing metastases were injected 6 h after the first radiotherapy session. Their accumulation reached a maximum at 3 h after injection. After the second radiotherapy session, the microcapsules released carboplatin, which reduced the number of metastases; however, this reduction was not significant.

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Physical Sciences and Engineering Materials Science Surfaces, Coatings and Films
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