Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1682340 | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms | 2009 | 4 Pages |
Abstract
Here we used cytokinesis-block micronucleus assay to measure the biological response along the penetrate depth of ions in water in human lymphocytes exposed to 100Â MeV/u incident carbon ions in vitro. Polyethylene shielding was used to change the penetration depth of ions in water. A quantitative biological response curve was generated for micronuclei induction. The results showed a marked increase with the penetrate depth of ions in water in the micronuclei formation, which was consistent with a linear-energy-transfer dependent increase in biological effectiveness. The dose-response relationship for MN information was different at different penetrate depth of ions in water, at the 6 and 11.2Â mm penetrate depth of ions in water, the dose-response relationships for the micronucleus frequencies induced by carbon ions irradiation were linear; while it was power function at 17.1Â mm penetrate depth.
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Authors
Z.Z. Wang, W.J. Li, D.J. Zhi, Y. Qu, X.G. Jing,