Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1695652 | Applied Clay Science | 2011 | 4 Pages |
The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
Research highlights► Intercalation of Lidocaine in the interlayer of montmorillonite by ion exchange. ► Blending of hybrid with alginate to retard the release in gastric environments. ► In vitro Lidocaine release from hydrogel composites.