Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1696117 | Applied Clay Science | 2009 | 6 Pages |
Abstract
Vitamin B1 (thiamine hydrochloride, VB1) intercalated into montmorillonite (MMT), which was characterized by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), and thermo gravimetric analysis (TGA). The adsorption of VB1 on MMT increased with increase in reaction temperature. The adsorption isotherms were fitted by the Langmuir model. About 34 and 64% of the intercalated VB1 was released within 10 h, in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) respectively at 37 ± 0.5 °C. The release profile of VB1 followed the Higuchi kinetic model and the diffusion-controlled mechanism. During in vitro release experiments VB1 was released from MMT–VB1 steadily as a function of pH.
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Authors
Ghanshyam V. Joshi, Hasmukh A. Patel, Bhavesh D. Kevadiya, Hari C. Bajaj,