Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1696212 | Applied Clay Science | 2008 | 9 Pages |
Abstract
A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.
Related Topics
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Authors
Hyun Jung, Hyun-Mi Kim, Young Bin Choy, Seong-Ju Hwang, Jin-Ho Choy,