Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
170250 | Comptes Rendus Chimie | 2015 | 6 Pages |
Abstract
A new multicomponent reaction (MCR) was found: a sodium acetate-catalyzed transformation of salicylaldehydes, malononitrile and 4-hydroxy-6-methyl-2H-pyran-2-one in ethanol results in the fast (30 min) and efficient formation of new 4-pyrano-substituted 2-amino-4H-chromenes in 86–96% yields. The same transformation initiated by grinding in mortar in the presence of sodium acetate or potassium fluoride results in a faster (15 min) formation of 4-pyrano-substituted 2-amino-4H-chromenes in 80–90% yields. This novel ‘one-pot’ process opens an effective and convenient way to pyrano-functionalized 2-amino-4H-chromene systems, which are promising compounds for different biomedical applications.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Anatoly N. Vereshchagin, Michail N. Elinson, Fedor V. Ryzhkov, Ruslan F. Nasybullin, Sergey I. Bobrovsky, Alexander S. Goloveshkin, Mikhail P. Egorov,