Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
170332 | Comptes Rendus Chimie | 2014 | 7 Pages |
Abstract
1H-Pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates possess a broad range of applications as active compounds in the pharmacological and biological fields. We developed an efficient and ecofriendly silica gel-supported tungstic acid (STA)-catalyzed one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates by a three-component reaction of an aldehyde, a malononitrile/ethyl cyanoacetate and a phthalhydrazide under solvent-free conditions. The major advantages of the present method are experimental simplicity, use of an inexpensive and ecofriendly reusable catalyst, good yields, and short reaction times.
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Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
M. Veeranaryana Reddy, P. Chenna Rohini Kumar, G. Chandra Sekhar Reddy, C. Suresh Reddy,