Simultaneous determination of acetaminophen, dopamine and ascorbic acid using a PbS nanoparticles Schiff base-modified carbon paste electrode

A highly sensitive method was investigated for the simultaneous determination of acetaminophen (AC), dopamine (DA), and ascorbic acid (AA) using a PbS nanoparticles Schiff base-modified carbon paste electrode (PSNSB/CPE). Differential pulse voltammetry peak currents of AC, DA and AA increased linearly with their concentrations within the ranges of 3.30 × 10−8–1.58 × 10−4 M, 5.0 × 10−8–1.2 × 10−4 M and 2.50 × 10−6–1.05 × 10−3 M, respectively, and the detection limits for AC, DA and AA were 5.36 × 10−9, 2.45 × 10−9 and 1.86 × 10−8 M, respectively. The peak potentials recorded in a phosphate buffer solution (PBS) of pH 4.6 were 0.672, 0.390, and 0.168 V (vs Ag/AgCl) for AC, DA and AA, respectively. The modified electrode was used for the determination of AC, DA, and AA simultaneously in real and synthetic samples.