[bmim]BF4/[Cu(Im12)2]CuCl2 as a novel catalytic reaction medium for click cyclization

Herein, a new application of an ionic liquid containing copper (I), ([Cu(Im12)2]CuCl2), is introduced. This ionic liquid was used as an efficient catalyst for the click cyclization between organic azides and terminal alkynes in various solvents. Then, the mixture of [bmim]BF4/[Cu(Im12)2]CuCl2 was used as a green catalytic medium for the multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from α-halo ketones. The reactions were performed efficiently in this mixture and excellent yields were obtained in all cases. This catalytic reaction medium was recycled five times without significant loss of activity.